Institut Curie

6 Jobs

2,782 Employees

About the Company

L’Institut Curie, premier centre français de recherche et de lutte contre le cancer, associe un centre de recherche de renommée internationale et un ensemble hospitalier de pointe qui prend en charge tous les cancers y compris les plus rares. Fondé en 1909 par Marie Curie, l’Institut Curie rassemble sur 3 sites (Paris, Saint-Cloud et Orsay) 3 800 chercheurs, médecins et soignants autour de ses 3 missions : recherche, soins et transmission des savoirs. Fondation reconnue d’utilité publique habilitée à recevoir des dons et des legs, l’Institut Curie peut, grâce au soutien de ses donateurs, accélérer les découvertes et ainsi améliorer les traitements et la qualité de vie des malades.

Listed Jobs

Company Name: Institut Curie
Job Title: Stage Master 2 (H/F) : « Production acoustique par des oscillateurs critiques couplés dans un modèle non linéaire de la cochlée humaine »
Job Description: **Job Title** Master 2 Internship – Acoustic Production via Coupled Critical Oscillators in a Nonlinear Model of the Human Cochlea **Role Summary** The internship involves theoretical and computational research on cochlear mechanics. The intern will model cochlear cells as critical oscillators, analyze wave reflections, and study otoacoustic emissions. Collaboration with an interdisciplinary team will integrate analytical insights with experimental data. **Expectations** - Full‑time commitment for 2–6 months starting early 2026. - Deliver quantitative models, numerical simulations, and analytical findings. - Communicate results clearly in written reports and oral presentations. **Key Responsibilities** - Develop and implement numerical models of cochlear mechanics in Python. - Simulate coherent wave reflections and analyze their impact on otoacoustic emissions. - Conduct bifurcation (Hopf) analysis of coupled oscillator systems. - Produce analytical solutions and numerical algorithms for the non‑linear cochlear model. - Collaborate with experimental teams to compare simulation results with recorded data. - Maintain clear documentation of code, methodology, and results. - Present progress and findings to the research group. **Required Skills** - Proficient in Python programming (numerical libraries, simulation packages). - Strong background in numerical methods and dynamical systems analysis. - Ability to perform analytical modeling and bifurcation theory. - Excellent written and oral communication in English. - Self‑driven, capable of independent project management, and collaborative within a multidisciplinary team. **Required Education & Certifications** - Current enrolment in a Master 2 (MSc) program in physics, applied mathematics, computational biology, or a closely related field. - Coursework covering differential equations, dynamical systems, numerical analysis, and PDE modeling. - Demonstrated experience with scientific programming and simulation. - Fluency in English (oral and written).

Paris, France

On site

28-11-2025

Company Name: Institut Curie
Job Title: Ingénieur.e en Biologie (F/H)
Job Description: Job title: Biology Engineer (Cellular & Molecular) Role Summary: Support research on double‑strand DNA break repair in human cells by developing and applying CRISPR‑based methods. Maintain mammalian cell cultures, perform electroporation and downstream molecular analyses, and collaborate closely with investigators to analyze experimental and genomic data. Expectations: - Perform laboratory work independently and as part of a multidisciplinary team. - Demonstrate meticulous organization, data integrity, and strong analytical skills. - Communicate findings effectively in English. Key Responsibilities: - Maintain and passage mammalian cell lines for experimental use. - Execute electroporation protocols and CRISPR‑mediated induction of DNA double‑strand breaks. - Conduct downstream analyses: PCR, RT‑qPCR, DNA purification, qPCR, ChIP‑seq library preparation, and genomic bank creation. - Process and analyze imaging data and molecular assays. - Collaborate with researchers to interpret experimental and genomic results and advance project milestones. Required Skills: - Proficiency in mammalian cell culture and cell line maintenance. - Experience with CRISPR genome editing and electroporation techniques. - Competence in PCR, RT‑qPCR, DNA purification, library preparation, and basic bioinformatics data handling. - Strong organizational, autonomous working, and teamwork abilities. - Fluency in English (written and spoken). Required Education & Certifications: - Licence (Bachelor’s) or Master’s (M2) in Molecular & Cellular Biology, Biotechnology, or a related field. - Minimum 2–3 years of practical experience in mammalian cell culture; CRISPR editing experience is highly desirable.

Company Name: Institut Curie
Job Title: Ingénieur.e en radiobiologie (F/H)
Job Description: Job Title: Radiobiology Engineer (F/M) Role Summary: Conduct in‑vivo radiation therapy research, design and execute animal protocols, and analyze biological data to validate novel FLASH‑VHEE radiotherapy technology in a multidisciplinary team. Expectations: 12‑month renewable contract, full‑time, starting spring 2026. Key Responsibilities: • Design and implement in‑vivo experiments, prepare protocols, and submit ethics approvals. • Perform animal handling: intraperitoneal/IP and intravenous/IV injections, weighing, anesthesia, euthanasia, and monitor clinical parameters. • Process and analyze biological samples (genotyping, histology, immunofluorescence, flow cytometry, PCR). • Collect, organize, analyze data, and maintain electronic lab notebooks. • Collaborate with radiotherapists, physicists, postdocs, and clinicians. Required Skills: • Proficiency in animal manipulation techniques (IP/IV injection, anesthesia, euthanasia). • Experience with histology, cytometry, molecular biology (PCR). • Strong scientific rigor, observational skills, critical thinking. • Excellent written and oral communication in French; technical English preferred. • Ability to write protocols and ethics submissions. • Self‑organized, autonomous, and team‑collaborative. Required Education & Certifications: • Minimum Master’s (MSc) or Engineer degree (Bac+5) in Biology, Biotechnology, Life Sciences, or Physiology. • 2–5 years of in‑vivo research experience (internship, apprenticeship, or comparable role). • Specific training in animal experimentation – user level (Category B) required; designer level (Category C) preferred. • Valid French animal experimenter license (Category B) and any additional certification as needed.

Company Name: Institut Curie
Job Title: Postdoctorat en immuno-oncologie (F/H)
Job Description: **Job Title:** Postdoctoral Researcher – Immuno‑Oncology (F/H) **Role Summary:** Conduct independent research to identify and validate tumor‑specific neo‑antigens in non‑small cell lung cancer (NSCLC). Characterize neo‑antigen‑specific T‑cell responses using immunopeptidomics, flow cytometry, single‑cell technologies, tetramer staining, and functional cytotoxicity assays. Collaborate with a multidisciplinary team to generate data supporting translational immunotherapy strategies. **Expectations:** - Deliver high‑quality experimental data within project timelines. - Apply rigorous scientific methodology and maintain detailed documentation. - Analyze and interpret complex immunological datasets, integrating bioinformatic insights when applicable. - Communicate findings effectively in English through reports, presentations, and manuscripts. - Contribute to a collaborative, interdisciplinary team environment. **Key Responsibilities:** - Perform in‑silico neo‑antigen prediction and validate candidates via immunopeptidomics. - Isolate and phenotype tumor‑infiltrating and peripheral T cells using flow cytometry and tetramer labeling. - Execute single‑cell RNA‑seq and related analyses to define T‑cell subsets and states. - Conduct functional assays (e.g., ex vivo cultures, killing assays) to assess T‑cell reactivity and cytotoxicity. - Process and analyze blood and tumor samples from NSCLC patients undergoing immunotherapy. - Maintain laboratory equipment, reagents, and compliance with safety and data integrity standards. - Prepare technical reports, figures, and contribute to scientific publications and conference abstracts. **Required Skills:** - Expert proficiency in flow cytometry (experimental design, panel development, data analysis). - Strong background in human immunology, cancer biology, and immunotherapy concepts. - Hands‑on experience with immunopeptidomics, tetramer assays, and functional cytotoxicity testing. - Familiarity with single‑cell sequencing (library preparation, bioinformatic pipelines) is highly desirable. - Ability to conduct statistical analysis and interpret complex datasets; basic bioinformatics skills a plus. - Excellent analytical, problem‑solving, and scientific writing abilities. - Fluent in English (written and spoken); French not required. - Demonstrated teamwork and proactive, dynamic attitude toward research innovation. **Required Education & Certifications:** - Ph.D. in Immunology, Molecular & Cellular Biology, Biotechnology, or a closely related discipline. - Proven expertise in human immunology and oncology research. - Certification or documented training in flow cytometry is mandatory. - No additional certifications required; eligibility to work in the host country is assumed.

Paris, France

Hybrid

11-02-2026

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