- Company Name
- Immunocore
- Job Title
- Senior Mammalian Upstream Process Development Scientist I | FTC 9 months
- Job Description
-
**Job Title:**
Senior Mammalian Cell Line Development Scientist
**Role Summary:**
Lead the design, optimization, and scale‑up of mammalian cell lines for the production of complex biopharmaceuticals. Independently plan and execute laboratory investigations, analyze data, and provide technical oversight for cell line development in upstream process development. Collaborate across CMC and research teams, supporting GMP manufacturing and regulatory submissions.
**Expectations:**
* Manage end‑to‑end cell line development projects, from vector design to bioreactor scale‑up.
* Deliver high‑quality data and reports that meet regulatory and quality system standards.
* Mentor junior staff and contribute to continuous improvement of laboratory practices.
**Key Responsibilities:**
* Design and construct expression vectors, perform cloning, and optimize gene/gene‑vector arrangements for transient and stable mammalian systems.
* Generate, screen, and validate cell lines, assessing product yield and quality using Octet BLI, HPLC, and related analytical techniques.
* Scale‑up cell culture processes in bioreactors, supporting candidate nomination and transfer to CDMOs.
* Design and conduct experiments to support GMP manufacturing, pre‑clinical, clinical, and analytical assays, and regulatory submissions.
* Maintain up‑to‑date laboratory notebooks, reports, and documentation in line with quality standards.
* Lead or contribute to projects, setting priorities, and making data‑driven decisions.
* Provide technical guidance on equipment operation, safety, and troubleshooting; recommend new instrumentation.
* Communicate findings through written reports and presentations to scientific, management, and partner audiences.
* Champion Health & Safety practices and deliver ad‑hoc training as needed.
**Required Skills:**
* Expertise in mammalian cell line development for complex biotherapeutic production.
* Proficiency in vector design, molecular cloning, and gene expression optimization.
* Strong analytical skills with experience in Octet BLI, HPLC, and related protein quality assessments.
* Ability to scale‑up cell culture processes to bioreactor volumes and support CDMO launch.
* Independent experimental design, execution, and data interpretation.
* Proficiency in laboratory record‑keeping, regulatory documentation, and quality system compliance.
* Excellent written and verbal communication, presentation, and mentoring capabilities.
* Knowledge of GMP manufacturing requirements and regulatory submission processes.
**Required Education & Certifications:**
* Bachelor’s or Master’s degree in Molecular Biology, Biotechnology, Chemical Engineering, or related field.
* At least 4–6 years of bench‑based experience in mammalian cell line development, molecular biology, and biopharmaceutical manufacturing.
* Certifications or training in Good Manufacturing Practice (GMP) and laboratory safety preferred.